CACLP product | Let us talk about Blood Lipid.

Last time, we talked about our liver, which is sharing  all the suffering with our body. We have known that our liver became a “hard-hit area” with a high incidence of diseases due to undertaking important work for the operation of human body functions. However, the biggest risk to human health is a potential killer: cardiovascular disease.

世间五味,最抚人心。

Liver

With the improvement of living standards and the rise of late-night snacks, people have gradually developed the eating habit of heavy oil and spicy food, which seems to improve the quality of life, but when the “spicy” taste becomes fashionable, invisible killers are gradually coming to us near. The picture below shows the changes in our blood cholesterol and triglyceride levels when we enjoy the gluttonous feast. It is changes in these indicators that cause cardiovascular disease.

On June 23, 2022, the China Cardiovascular Health and Disease Report 2021 showed that the incidence and fatality rate of cardiovascular diseases in China still ranked first, with rural and urban cardiovascular diseases accounting for 46.74% and 44.26% of the causes of death respectively in 2019, and 2 out of every 5 deaths died of cardiovascular disease. It is estimated that the number of patients with cardiovascular diseases is 330 million, including stroke 13 million, coronary heart disease 11.39 million, heart failure 8.9 million, pulmonary heart disease 5 million, atrial fibrillation 4.87 million, rheumatic heart disease 2.5 million, congenital heart disease 2 million, lower limb arterial disease 45.3 million, hypertension 245 million. From these shocking numbers, it can be seen that the prevention and control of cardiovascular disease is still in a strict state, and the inflection point has not yet come.

At present, China has become one of the countries with the highest number of deaths from cardiovascular diseases in the world.

The report also pointed out the five main factors that could cause cardiovascular diseases: High-salt diet, Smoking, Spicy, Frequent hotpot, Barbecue, lack of physical activity & so on…

 

In the process of preventing cardiovascular disease, we not only need to improve our living habits, but also conduct regular physical examinations. This is a very important means, especially the detection of cardiovascular disease risk indicators in the blood, which will provide important guidance for our early preventing cardiovascular disease.

 

Lipid testing is mainly a quantitative determination of lipids contained in the blood. It is mainly to determine the level of total cholesterol, triglycerides, High-density lipoprotein cholesterol low-density lipoprotein cholesterol in the serum.

 

Six items of blood lipids: triglycerides, total cholesterol, high-density lipoprotein,  low-density lipoprotein,  apolipoprotein A, apolipoprotein B.

Hzymes Biotech provides relevant raw materials and raw reagent manufacturing services for biochemical testing reagent manufacturers.

Cholesterase 

Product advantages: 

  • Molecularly modified.
  • esterases can be provided with different substrate selectivity to meet different customer needs.
  • Provide technical solutions for high and low density reagents that can replace imported brands.
  • Formulated high & low-density reagents are suitable for third-party quality control.
table 1 for Lipids Article

Cholesterol oxidase

Product advantages: 

  • Good compatibility with multi-manufacturer cholesterase.
  • The specific vitality and thermal stability are comparable to imported brands.
table 2 for Lipids Article

High-density lipoprotein cholesterol (HDL-C) test kit (direct method)
Product advantages:

  • Core enzyme raw materials are completely self-produced.
  • Clinical results can be compared with different brands of products, and the correlation is good.
  • Strong anti-interference ability, good stability.
table 3 for lipids article

Low-density lipoprotein cholesterol (HDL-C) test kit(Direct Law)
Product advantages:

  • Core enzyme raw materials are completely self-produced.
  • Compared with products from different brands, clinical results correlation is good
  • Strong anti-interference ability
  • Good stability.

In addition to the above indicators, we also need to test independent indicators that can predict cardiovascular disease risk, such as homocysteine.

 

Homocysteine (Hcy) is a sulfur-containing amino acid in the human body that is an important intermediate in the metabolism of methionine and cysteine. Many scholars believe that the increase of Hcy content in blood has become an independent risk factor for atherosclerosis, which can increase the risk of stroke death several times in three-quarters of hypertensive patients.

The detection of homocysteine has gradually become a compulsory examination item for hospitalization in many hospitals in China and a routine physical examination for people over 40 years old. Causes of elevated levels of homocysteine in the human body include: genetic defects, disease factors, drug factors, lifestyle and other reasons.

 

Hzymes Biotech provides the core raw materials of Homocysteine Detection Reagent (Enzymatic Method) and the original reagent manufacturing service.

 

Homocysteine Detection Reagent  (Enzymatic Method)
Product advantages:

  • Excellent performanceby Superior reagent formulation, formulated with lyophilized enzyme powder, comprehensive stability improvement. 
  • Sealed and stored at 2-8 °C for more than 18 months, it can be stably stored in the machine for more than 35 days after opening.
  • The accuracy is high. R2 test results can reachmore than 0.99, compared with the of imported manufacturers.
LIpids article img 2
LIpids article img 1

We can customize the formula for you with different ratios, because we have mastered the core formula.

Cyst sulfate synthase (CBS), cyst sulfate lyase (CBL).

Product disturbance: 

  • We can effectively guide the dosage of reagents and reduce the batch difference due to the product form of the lyophilized enzyme powder and the accurate quantification of the specific activity of the enzyme powder.
  • We can effectively reduce the difficulty of reagent developmentbecause our lyophilized enzyme powder has good solubility, and thermal acceleration is not easy to precipitate.
  • We canreduce the difficulty of reagent development because of our product’s high specific activity, lower amount of enzyme powder feeding, and the less introduction of interference. 
  • We can assist customers to complete the self-production of the reagent, because we can provide both core enzyme raw materials and reagent formulation cooperation solutions
CBS

Our cystathionine synthase has the best half-life among similar products, and the reagents developed under the same system have better long-term stability. At the same time, our specific activity of the enzyme is the highest, which reduces the interference caused by the input of enzyme powder.

cystathionine lyase

The half-life of our cystathionine lyase is the best among similar products, so the long-term stability of the reagents we developed under the same system is better.

When the risk factors of blood lipids progress to the stage of cardiovascular disease, damage to the myocardium and aorta will also appear, especially for the damage to the myocardium. In the biochemical myocardial injury detection project, creatine kinase isoenzyme is an important indicator, and other myoglobin and troponin as a combination index for chest pain detection provide important indications for the evaluation and diagnosis of myocardial injury.

 

Creatine kinase MB isoenzyme (CK-MB) is a hybrid dimer composed of M and B subunits, and it is the most specific enzyme in myocardial enzyme profile. The detection of Creatine kinase MB isoenzyme (CK-MB) is used in the early diagnosis of acute myocardial infarction (AMI), and it is regarded as the “gold standard” for myocardial enzymatic diagnosis, because The increased activity of CK-MB in serum is recognized as an important indicator for the diagnosis of acute myocardial infarction and the presence or absence of myocardial necrosis.

Hzymes Biotech can provide CK-MB detection reagent (enzymatic) original manufacturing services.

 

CK-MB detection reagent (enzymatic method)

Product advantages:

  • Benchmark with first-class brands such as Desai and Beckman, and the accuracy of measurement is high;
  • Good stability of opening bottle, at least up to 30 days or so;
  • Clinical negative values are low.

Hzymes quality control in production is strictly in accordance with requirements of the industry regulations; Our process is stable, which can assure that the difference between batches is stable, and the results of different batches are qualified

CK-HB

At present, cardiovascular disease has become the first factor of death in China, and the demand for cardiovascular testing after chest pain diagnosis and blood lipid items during routine physical examination is growing. Hzymes biotech can provides a full set of testing raw materials and original reagent manufacturing services for in vitro diagnostic reagent manufacturers, and we are willing to work with industry colleagues to improve product quality, control production and manufacturing costs, and jointly cope with the impact of volume procurement. We look forward to contributing to the improvement of people health by provide more efficient and accurate detection reagents for hospitals and patients!

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