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Let us talk about Liver: Causes and prevention of liver damage

When it comes to metabolic digestion, the liver stands out as the most vital organ in the human body. Apart from its role in metabolism and secretion of digestive juices, the liver possesses exceptional abilities in detoxification and early hematopoiesis. Its remarkable capacity for compensation truly exemplifies its status as an exemplary worker. With approximately 300 billion active cells, the liver displays a remarkable feat: when a portion of its cells are damaged, the remaining cells can swiftly step up and fulfill the necessary functions, effectively replacing the impaired cells


Liver disease 

Due to the liver’s crucial role in processes such as metabolism, digestion, attenuation, and hematopoiesis, it continually adapts to the environment, enhancing the body’s ability to survive in a complex world. However, the concerning statistics on liver diseases highlight a significant disparity between our current efforts to protect the liver and its invaluable contributions to the body.

Over the past few decades, liver disease has emerged as a prominent cause of death and illness worldwide. According to the Global Burden of Disease Project, liver disease accounted for over 2 million deaths in 2010, making it the primary cause of mortality. These deaths were attributed to conditions such as acute hepatitis, cirrhosis, and liver cancer, encompassing approximately 4% of all global deaths.

Addressing the Urgent Need for Liver Disease Prevention and Timely Diagnosis in China

Liver-functionChina, as a large country grappling with liver disease, presented staggering statistics in 2020. Chronic liver diseases, including chronic hepatitis, fatty liver, and cirrhosis, affected a potential population of over 447 million individuals, accounting for 62.58% of the total populace. These alarming figures emphasize the need to prioritize early detection, timely diagnosis, and prompt treatment to prevent the adverse impact of irreversible liver diseases, including a decline in quality of life and even mortality. Implementing effective measures for liver disease diagnosis and treatment is crucial in addressing this pressing issue.

Preventive medical examinations and diagnostic procedures play a vital role in the prevention and treatment of liver diseases. Evaluating liver function involves the direct, effective, and straightforward detection of protein and enzyme indices—a fundamental aspect of the assessment process.

Liver Function test

Liver function tests employ various biochemical methods to examine multiple indicators associated with liver function and metabolism. Given the diverse nature of liver functions, there exists a wide range of indicators within these tests.

  1. 1) Indicators reflecting liver parenchymal damage: AST/ALT
  2. 2) Indicators reflecting bilirubin metabolism and cholestasis: TBIL/DBIL/rGT/TBA, etc.
  3. 3) Indicators reflecting the synthetic function of the liver: TP/ALB, etc.


Comprehensive liver function assessments consist of eighteen specific items, including alanine transaminases, aspartate aminotransferases, total bilirubin, r-glutamyltransferase, alkaline phosphatase, total protein, albumin, globulin, white/spheroid ratio, direct bilirubin, indirect bilirubin, adenosine deaminase, total bile acids, proalbumin, alpha-fetoprotein, 5′-nucleotides, cholinease, and a-L-fucosidase.

As a leading upstream raw material enterprise, particularly in the core raw materials of biochemical reagents, Hzymes has established a solid reputation for being a reliable partner to biochemical reagent production companies. In light of the current challenging circumstances, Hzymes stands as a steadfast support system for every customer. Whether it entails efficient supply chain management or the meticulous selection and substitution of essential raw materials, Hzymes remains committed to delivering top-notch products and comprehensive services to all its valued clients.

Hzymes products related to liver function testing


Featured Product Recommendation


Total bile acid detection kit (enzyme cycle method). (TBA)


  • 1) Cyclic enzyme detection, suitable for a variety of automatic biochemical analyzers, convenient and fast
  • 2) Effectively resists interference from hypolipidemia and hemolytic samples
  • 3) Good stability, sealed and stored at 4 °C for 1 year, it can be stored stably for 28 days after opening
  • 4) High accuracy, can accurately target Langdao quality control

3α-Hydroxysteroid dehydrogenase (3α-HSD)


  • 1) Small difference between batches, stable, performance;
  • 2) Excellent cost performance;
  • 3) High vitality and low feeding volume

Thio-Coenzyme (Thio-NAD)


  • 1) The production cycle is short and there is stock
  • 2) High purity, few impurities
  • 3) Water solubility is good, and it is not easy to precipitate
  • 4) It can effectively reduce the amount of feeding

Fucoidase (AFU)


  • 1) Genes are derived from seafloor thermophilic microorganisms
  • 2) Excellent thermal stability, 90°C half-life 214min, 37°C incubation for 10 days enzymatic activity unchanged
  • 3) Enzyme activity is not inhibited by EDTA, NaN3, PC300, travanone
Fucoidase (AFU)

2-Chloro-4-nitrophenyl-α-L-fucoside (CNP-AFU)


  • 1) High purity, less impurity introduction, reduce the difficulty of reagent development
  • 2) Single batch production up to 10 kg with small batch-to-batch variations and CV between batchesis less than 5% 
  • 3) The water solubility is good, and the preparation reagent does not precipitate at low temperature
2-Chloro-4-nitrophenyl-α-L-fucoside (CNP-AFU)

L-r-Glutamyl-3-hydroxy-4 nitroaniline sodium salt (Glupa-C)


  • 1) The production cycle is short and there is stock 
  • 2) The production capacity of a single batch is large, and the difference between batches is controllable
  • 3) High purity, low impurities, ≥ 99% purity (HPLC)
  • 4) Validated in the GGT system, it can be switched seamlessly

Hzymes Biotech is willing to share the “liver pain” with the in vitro diagnostic industry, and make its own contribution to the prevention and treatment of global liver disease!


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